Abstract Background Targeting glucose uptake by glucose transporter (GLUT) inhibitors is a therapeutic opportunity, but efforts on GLUT inhibitors have not been successful in the clinic and the underlying mechanism remains unclear.We aim to identify the key metabolic changes responsible for cancer cell survival from glucose limitation and elucidate
Abstract Background The Rohingya ethnic minority population in northern Rakhine state, Myanmar, have experienced some of the most protracted situations of persecution.Government-led clearance operations in August 2017 were one of many, but notably one of the most devastating, attacks on the population.The study aimed to conduct a multiphase mixed-m
Abstract Background Successful deployment of clinical prediction models for clinical deterioration relates not only to predictive performance but to integration into the decision making process.Models may demonstrate good discrimination and calibration, but fail to match the needs of practising acute care clinicians who receive, interpret, and act
Identification and interpretation of pathologies in the fossil record allows for unique insights into the life histories of extinct organisms.However, the rarity of such finds limits not only the sample size for palaeopathologic studies, but also the types of analyses that may be performed.In this study, we present the first occurrence of a palaeop